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PTSD: National Center for PTSD


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John H. Krystal, MD


About Us

This section is about our Mission, Vision, Staff, & Press Room

This section is about our Mission, Vision, Staff, and Press Room

John H. Krystal, MD

John H. Krystal, MD


Clinical Neurosciences Division

See staff directory for contact information.

Academic Appointment

  • Yale University School of Medicine, Robert L. McNeil Jr. Professor of Psychiatry and Professor of Neurobiology; Chair, Department of Psychiatry


  • Residency in Psychiatry, Yale University School of Medicine, 1984-1988
  • Internship, Hospital of St. Raphael, 1984-1985
  • Yale University, M.D., 1984
  • University of Chicago, B.A., 1980

Expertise and Interests

  • Neurobiology of PTSD (PET, MRS, MRI, EEG, experimental psychopharmacology)
  • Genetics of PTSD/resilience
  • Pharmacotherapy of PTSD

Membership in Professional Societies

  • Editor, Biological Psychiatry
  • Past-president, American College of Neuropsychopharmacology
  • Board of Directors (past/current): International Society of Traumatic Stress Studies, Research Society on Alcoholism, Society of Biological Psychiatry, Molecular Psychiatry Society
  • National Service (selected list): Department of Defense "Defense Health Board" Psychological Health Subcommittee, Chair of the NIMH Board of Scientific Counselors, Member of the National Alcohol Advisory Panel (NIAAA Council)
  • Institute of Medicine, National Academy of Sciences

Awards and Honors

  • Certificate of Appreciation from Assistant Deputy Under Secretary for Health/US Department of Veterans Affairs for contributions to PTSD
  • Danielli Award and President's Award, International Society for Traumatic Stress Studies
  • Anna-Monika Foundation Depression Research Award (shared with Aaron T. Beck, Gerard Sanacora)
  • Joel Elkes Award, American College of Neuropsychopharmacology
  • Exemplary Psychiatrist Award, National Alliance on Mental Illness

Selected Publications

Pietrzak, R. H., Henry, S., Southwick, S. M., Krystal, J. H., & Neumeister, A. (2013). Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology. Molecular Psychiatry, 18, 399-401. doi:10.1038/mp.2012.60

Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N. R., Ennis, D. J., Niciu, M. H., Morgan, P. T., Surti, T. S., Bloch, M. H., Ramani, R., Smith, M. A., Wang, X. J., Krystal, J. H., & Corlett, P. R. (2012). NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 109, 16720-16725. doi:10.1073/pnas.120849410

Petrakis, I. L., Ralevski, E., Desai, N., Trevisan, L., Gueorguieva, R., Rounsaville, B., & Krystal, J. H. (2012). Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology, 37, 996-1004. doi:10.1038/npp.2011.283

Krystal, J. H., Rosenheck, R. A., Cramer, J. A., Vessicchio, J. C., Jones, K. M., Vertrees, J. E., Horney, R. A., Huang, G. D., & Stock, C. (2011). Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: A randomized trial. The Journal of the American Medical Association, 306, 493-502. doi:10.1001/jama.2011.1080

Murrough, J. W., Huang, Y., Hu, J., Henry, S., Williams, W., Gallezot, J. D., Bailey, C. R., Krystal, J. H., Carson, R. E., & Neumeister, A. (2011). Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biological Psychiatry, 70, 1033-1038. doi:10.1016/j.biopsych.2011.07.003

Members of the press interested in contacting this staff member to schedule an interview should reach out to the Division contact for the press.

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