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PTSD: National Center for PTSD

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Paul Holtzheimer, MD

   

Paul Holtzheimer, MD

Portrait of Paul Holtzheimer, MD

Deputy Director for Research

Executive Division

Email: Paul.Holtzheimer@va.gov

Academic Appointment

  • Geisel School of Medicine at Dartmouth, Professor of Psychiatry and Surgery

Education and Professional Certifications

  • Emory University, School of Public Health, MS (Clinical Research)
  • University of Washington School of Medicine, Senior Research Fellow (Transcranial Magnetic Stimulation) and Psychiatry Residency
  • Geisel School of Medicine at Dartmouth, MD
  • Pacific Lutheran University, Biology, Philosophy and Psychology, BA and BS

Expertise and Interests

  • Treatment-resistant mood and anxiety disorders
  • Focal brain stimulation (transcranial magnetic stimulation, deep brain stimulation, transcranial direct current stimulation, vagus nerve stimulation)
  • Electroconvulsive therapy
  • Brain imaging of mood and anxiety disorders

Featured Publications

Tozzi, L., Bertrand, C., Hack, L. M., Lyons, T., Olmsted, A. M., Rajasekharan, D., Chen, T., Berlow, Y. A., Yesavage, J. A., Lim, K., Madore, M. R., Philip, N. S., Holtzheimer, P., & Williams, L. M. (2024). A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial. Nature Mental Health, 2(8), 987-998. https://doi.org/10.1038/s44220-024-00271-9 PTSDpubs id1644476 (PDF)

Madore, M. R., Kozel, F. A., Williams, L. M., Green, L. C., George, M. S., Holtzheimer, P. E., Yesavage, J. A., & Philip, N. S. (2022). Prefrontal transcranial magnetic stimulation for depression in US military veterans - A naturalistic cohort study in the Veterans Health Administration. Journal of Affective Disorders, 297, 671-678. https://doi.org/10.1016/j.jad.2021.10.025 PTSDpubs id1581876 (PDF)

Conroy, S. K., Malloy, S., Kelley, M. E., Filkowski, M. M., Trimble, R. M., Pirtle, M. E., Maher, A., Dreyer-Oren, S., Doucette, W., Roth, R. M., Aronson, J. P., Roberts, D. W., Choi, K. S., Mayberg, H. S., Holtzheimer, P. E. (2021). Left versus right subcallosal cingulate deep brain stimulation for treatment-resistant depression. Personalized Medicine in Psychiatry, 25-26, 100069. https://doi.org/10.1016/j.pmip.2021.100069 PTSDpubs id1566084 (PDF)

Lantrip, C., Delaloye, S., Baird, L., Dreyer-Oren, S., Brady, R. E., Roth, R. M., Gunning, F., & Holtzheimer, P. (2019). Effects of left versus right dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation on affective flexibility in healthy women: A pilot study. Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology, 32(2), 69-75. https://doi.org/10.1097/WNN.0000000000000190 PTSDpubs id1514401 (PDF)

Holtzheimer, P. E., Husain, M. M., Lisanby, S. H., Taylor, S. F., Whitworth, L. A., McClintock, S., Slavin, K. V., Berman, J., McKhann, G. M., Patil, P. G., Rittberg, B. R., Abosch, A., Pandurangi, A. K., Holloway, K. L., Lam, R. W., Honey, C. R., Neimat, J. S., Henderson, J. M., DeBattista, C., … Mayberg, H. S. (2017). Subcallosal cingulate deep brain stimulation for treatment-resistant depression: A multisite, randomised, sham-controlled trial. The Lancet Psychiatry, 4(11), 839-849. https://doi.org/10.1016/S2215-0366(17)30371-1

Key Projects

  • Targeted Brain Stimulation to Enhance Recovery After Shockwave-Induced Blast TBI: Identifying Neural Biomarkers to Guide Treatment. VA Merit; mPI (with Crystal Noller, PhD)
  • Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans with PTSD. VA CDA; Primary Mentor (PI: Crystal Lantrip, PhD)
  • Efficacy and Safety of Stellate Ganglion Block for Post-Traumatic Stress Disorder in Veterans. VA Merit; Local Site Investigator (mPIs: Michael Hollifield, MD and Charles Brock, MD)
  • Assessing an Electroencephalography (EEG) Biomarker of Response to Transcranial Magnetic Stimulation for Major Depression. VA Merit; mPI (with Noah Philip, MD)

    • Membership in Professional Societies

    • American College of Neuropsychopharmacology
    • Anxiety and Depression Association of America
    • International Society for Traumatic Stress Studies
    • Society of Biological Psychiatry

    Awards and Honors

    • George N. Thompson Award for Distinguished Service, Society of Biological Psychiatry
    • Brain Behavior Research Foundation (NARSAD) Independent Investigator Award
    • Brain Behavior Research Foundation (NARSAD) Young Investigator Award

    Members of the press interested in scheduling an interview please see the contact for the media page.

PTSD Information Voice Mail: (802) 296-6300
Email: ncptsd@va.gov
Also see: VA Mental Health

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