PTSD: National Center for PTSD
Clinical Trials Database: PTSD-Repository
Clinical Trials Database: PTSD-Repository
The PTSD Trials Standardized Data Repository (PTSD-Repository) is a large database that contains information extracted from more than 300 published randomized controlled clinical trials for PTSD.
It was created by the National Center for PTSD in partnership with the Agency for Healthcare Research and Quality (AHRQ) so that everyone—researchers, clinicians, patients, and policymakers—can easily access PTSD trial data.
Included Studies and Variables
The PTSD-Repository includes 318 PTSD clinical trials published between 1988 and 2019. Of these, 106 trials evaluated pharmacologic interventions (medications, medication-assisted psychotherapy) and 212 trials evaluated nonpharmacologic interventions (psychotherapies, complementary and alternative treatments, biological interventions).
These studies enrolled different types of participants who were exposed to a wide array of trauma types.
We extracted more than 70 descriptive variables from each trial, including:
- Study characteristics (study authors and year, design, how PTSD was diagnosed)
- Intervention characteristics (treatment description, frequency/duration, completion)
- Participant characteristics (age, gender, type of trauma, % with comorbid disorders)
- PTSD outcomes (% of participants that no longer had PTSD, effect size)
- Other outcomes (depression, anxiety, substance use, sleep, anger, quality of life, functioning)
A complete list of included variables and a detailed description of the methods can be found in the Full Report on the AHRQ website.
Learn more about the development of the PTSD-Repository from VA's HSR&D cyber-seminar: PTSD Trials Standardized Data Repository (PTSD-Repository): How we did it, what the data tell us, and how you can us it.
Download the PTSD-Repository
PTSD-Repository data is stored in two separate Microsoft Excel® Spreadsheets—one for pharmacologic studies and one for nonpharmacologic studies.
- Download Pharmacologic Trials Data (XLSX).
This spreadsheet includes studies in which at least some participants received medication as part of the trial.
- Download Non-Pharmacologic Trials Data (XLSX).
This spreadsheet includes studies in which participants did not receive medication as part of the trial.
Using the PTSD-Repository Data
The PTSD-Repository can support clinicians, researchers, administrators, patients, and family members to:
- Conduct research: Interested in conducting a systematic review or meta-analysis? Use the PTSD-Repository as a data source. Or, search the PTSD-Repository to identify gaps in the literature to inform your grant application.
- Enhance education: Giving a lecture or teaching a course? Use data or figures from the PTSD-Repository in your slides.
- Inform patients: Is your patient asking about a specific PTSD intervention? Search the PTSD-Repository to find out how many studies have evaluated this treatment.
- Learn about PTSD treatments: Heard about a specific treatment and want to learn how well it works? Search the PTSD-Repository to see what percent of participants lose their diagnosis of PTSD after treatment.
The data in the PTSD-Repository is publicly available and free to use. No permission is needed. We ask that if you use the data to:
- Email firstname.lastname@example.org and let us know how you intend to use the data. Then consider sharing with us if it was helpful and any publications based on the data. This will help us to make decisions about what variables people are interested in, which can inform future directions for the Repository.
- Where appropriate, cite the PTSD-Repository in your work. See below for citation.
Remember: Prior to using PTSD-Repository data for research purposes, please consult your local Institutional Review Board or appropriate research oversight committee to ensure that you are adhering to all policies for ethical research.
The National Center for PTSD will oversee an annual update during which newly published studies and additional variables of interest will be added to the PTSD-Repository.
Staff at the National Center for PTSD are currently working to develop an interactive web-application that will allow users to more easily view, search, and sort these data. Subscribe to the PTSD Monthly Update where we will announce the release of this web-application.
Questions or feedback about the PTSD-Repository? Email us: email@example.com
O'Neil, M., McDonagh, M., Hsu, F., Cheney, T., Carlson, K., Holmes, R., ...& Chou, R. (2019) Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: Groundwork for a Publicly Available Repository of Randomized Controlled Trial Data. Technical Brief No. 32. (Prepared by the Pacific Northwest Evidence-based Practice Center under Contract No. 290-2015-00009-I.) AHRQ Publication No. 19-EHC018-EF. Rockville, MD: Agency for Healthcare Research and Quality. doi.org/10.23970/AHRQEPCTB32
Posted final reports are located on the Effective Health Care Program search page https://effectivehealthcare.ahrq.gov/topics/ptsd-pharm-treatment/research