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PTSD: National Center for PTSD

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Irina Esterlis, PhD

Irina Esterlis, PhD

Irina Esterlis, PhD


Director, Molecular Imaging Program at Yale

Clinical Neurosciences Division

See staff directory for contact information.

Academic Appointment

  • Yale University, Associate Professor


  • University of Connecticut, Clinical Neuropsychology, Ph.D., 2005
  • University of Connecticut, Clinical Psychology, MA, 2003
  • State University of New York at Buffalo, Psychology, BA, 1999
  • State University of New York at Buffalo, Studio Art, BA, 1999

Expertise and Interests

  • Pathophysiology of mood and trauma disorders
  • Molecular imaging
  • Precision medicine in treatment of mood/trauma disorders

Membership in Professional Societies

  • Member International Neuropsychological Society
  • Member/Reviewer Society for Research on Nicotine and Tobacco
  • Member Society for Biological Psychiatry
  • Member American College for Neuropsychopharmacology
  • Member International Summit on Suicide Research
  • Member American Association for the Advancement of Sciences
  • Member Society for Neuroscience

Awards and Honors

  • 2019 American Association for the Advancement of Sciences, Symposia Chair
  • ACNP Young Investigator Travel Award
  • NIDA Women & Sex/Gender Junior Investigator Travel Award
  • ICANA Young Investigator Travel Award
  • CPDD Director's Travel Award

Selected Publications

Davis, M.T., Hillmer, A., Holmes, S.E., Pietrzak, R.H., DellaGiogia, N., Nabulsi, N, Matuskey, N., Angarita, G.A., Carson, R.E., Krystal, J.H., & Esterlis, I. (2019). In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. PNAS. 116, 11490-11495.

Holmes, S., Scheinost, D., Finnema, S., Naganawa, M., Davis, M.T., DellaGioia, N., Nabulsi, N, Matuskey, D., Angarita, G., Pietrzak, R., Duman, R., Sanacora, G., Krystal, J., Carson, R., & Esterlis I. (2019). Lower synaptic density is associated with depression severity and network alterations. Nature Communications. 10, 1529.

Holmes, S.E., Scheinost, D., DellaGioia, N., Davis, M, Matuskey, D., Pietrzak, R., Hampson, M., Krystal, J., & Esterlis, I. (2018). Cerebellar and prefrontal cortical alterations in PTSD: Structural and functional evidence. Chronic Stress.

Holmes, S.E., Girgenti, M.J., Davis, M.T., Pietrzak, R.H., DellaGioia, N., Nabulsi, N, Matuskey, D., Southwick, S., Duman, R., Carson, R.E., Krystal, J.H., & Esterlis, I., Traumatic Stress Brain Study Group. (2017). Altered metabotropic glutamate receptor 5 markers in PTSD: In-vivo and postmortem evidence. PNAS. 114, 8390-8395.

Abdallah, C.G., Hannestad, J., Mason, G.F, Holmes, S.E., DellaGioia, N., Sanacora, G., Jiang, L., Matuskey, D., Satodiya, R., Gasparini, F., Lin, X., Javitch, J., Planeta, B., Nabulsi, N., Carson, R.E., & Esterlis, I. (2017). mGluR5 and glutamate involvement in MDD: A multimodal imaging study. Biological Psych: CNN. 2, 449-456.

Members of the press interested in scheduling an interview please see the contact for the media page.

PTSD Information Voice Mail: (802) 296-6300
Also see: VA Mental Health