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PTSD: National Center for PTSD

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Matthew Girgenti, PhD


Matthew Girgenti, PhD

Matthew Girgenti, PhD

Research Biologist

Clinical Neurosciences Division

See staff directory for contact information.

Academic Appointment

  • Yale University, Assistant Professor of Psychiatry


  • Yale School of Medicine, Postdoctoral, Molecular Psychiatry and Bioinformatics, 2019
  • University of Connecticut, PhD, Physiology and Neurobiology, 2015
  • Fairfield University, BS, Molecular Biology, 2002

Expertise and Interests

  • Functional Genomics of Neuropsychiatric Disorders
  • Molecular and cellular mechanisms of traumatic stress
  • Psychiatric Genetics

Membership in Professional Societies

  • Society for Neuroscience
  • Society of Biological Psychiatry
  • International Psychiatric Genomics Consortium

Awards and Honors

  • ACNP Travel Award
  • Brain and Behavior Research Foundation Young Investigator Award
  • VA VISN1 Career Development Award

Selected Publications

Girgenti MJ, Wang J, Ji D, Cruz DA; Traumatic Stress Brain Research Group, Stein MB, Gelernter J, Young KA, Huber BR, Williamson DE, Friedman MJ, Krystal JH, Zhao H, Duman RS. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nat Neurosci. 2021 Jan;24(1):24-33.

Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ; Traumatic Stress Brain Study Group, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nat Commun. 2020 May 12;11(1):2360.

Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H; Department of Veterans Affairs Cooperative Studies Program (no. 575B); VA Million Veteran Program, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nat Genet. 2021 Feb;53(2):174-184.

Girgenti MJ, Wohleb ES, Mehta S, Ghosal S, Fogaca MV, Duman RS. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Transl Psychiatry. 2019 Nov 11;9(1):292.

Girgenti MJ, Ghosal S, LoPresto D, Taylor JR, Duman RS. Ketamine accelerates fear extinction via mTORC1 signaling. Neurobiol Dis. 2017 Apr;100:1-8.

Members of the press interested in scheduling an interview please see the contact for the media page.

PTSD Information Voice Mail: (802) 296-6300
Also see: VA Mental Health