PTSD: National Center for PTSD

John H. Krystal, MD

Director

Clinical Neurosciences Division

See staff directory for contact information.

Academic Appointment

• Yale University, Robert L. McNeil, Jr., Professor of Translational Research; Professor of Psychiatry, Neuroscience, and Psychology; Chair, Department of Psychiatry

Education

• Yale University, Psychiatry Residency, 1988
• Yale University School of Medicine, M.D., 1984
• University of Chicago, Behavioral Sciences, B.A., 1980

Expertise and Interests

• Translational Neuroscience
• Pharmacotherapy
• Genetics

Membership in Professional Societies

• U.S. National Academy of Medicine (Co-Director, Section 7; Psychiatry/Neurology, 2018-present)
• Neuroscience Forum, U.S. National Academies of Science, Engineering, and Medicine (Co-Chair, 2019-present)
• American College of Neuropsychopharmacology (President, 2012)
• International College of Neuropsychopharmacology (President, 2016-2018)
• Society of Biological Psychiatry (Council, 2006-present)
• International Society of Traumatic Stress Studies (Board of Directors, 1988-1991)
• Research Society on Alcoholism (Board of Directors, 2005-2009)

Awards and Honors

• Colvin Prize, Brain and Behavior Research Foundation (2019)
• Edward H. Ahrens, Jr. Distinguished Investigator Award, Association for Clinical and Translational Science (2019)
• Gold Medal Prize, Society of Biological Psychiatry (2018)

Selected Publications

Davis, M.T., Hillmer, A., Holmes, S.E., Pietrzak, R.H., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G.A., Carson, R.E., Krystal, J.H., & Esterlis, I. (2019). In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proc Natl Acad Sci USA., 116(23), 11490-11495. doi: 10.1073/pnas.1818871116.

Holmes, S.E., Scheinost, D., Finnema, S.J., Naganawa, M., Davis, M.T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G.A., Pietrzak, R.H., Duman, R.S., Sanacora, G., Krystal, J.H., Carson, R.E., & Esterlis, I. (2019). Lower synaptic density is associated with depression severity and network alterations. Nat Commun, 4; 10(1):1529. doi: 10.1038/s41467-019-09562-7.

Homan, P., Levy, I., Feltham, E., Gordon, C., Hu, J., Li, J., Pietrzak, R.H., Southwick, S., Krystal, J.H., Harpaz-Rotem, I., & Schiller, D. (2019). Neural computations of threat in the aftermath of combat trauma. Nat Neurosci, 22(3):470-476. doi: 10.1038/s41593-018-0315-x.

Krystal, J.H., Abdallah, C.G. Averill, L.A., Kelmendi, B., Harpaz-Rotem, I., Sanacora, G., Southwick, S.M., & Duman, R.S. (2017). Synaptic loss and the pathophysiology of PTSD: Implications for ketamine as a prototype novel therapeutic. Curr Psychiatry Rep, 19(10):74. doi: 10.1007/s11920-017-0829-z.

Holmes, S.E., Girgenti, M.J., Davis, M.T., Pietrzak, R.H., DellaGioia, N., Nabulsi, N., Matuskey, D., Southwick, S., Duman, R.S., Carson, R.E., Krystal, J.H., Esterlis, I., & Traumatic Stress Brain Study Group (2017). Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proc Natl Acad Sci U S A, 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114.

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