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PTSD: National Center for PTSD

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Ke Xu, MD, PhD


Ke Xu, MD, PhD

Research Psychiatrist

Clinical Neurosciences Division

See staff directory for contact information.

Academic Appointment

  • Yale School of Medicine, Associate Professor


  • Yale School of Medicine, Resident, 2011
  • National Institute on Alcohol Abuse and Alcoholism Postdoctoral Fellow, 2007
  • Sichuan University, Huaxi School of Medicine, China Ph.D., 1998
  • Sichuan University, Huaxi School of Medicine, China M.B, 1985

Expertise and Interests

  • Epigenetics on stress and trauma
  • Biomarkers identification
  • Machine learning for treatment response

Membership in Professional Societies

  • Associate Member American College of Neuropsychopharmacology
  • Member: American Society of Human Genetics
  • Research Society on Alcoholism

Selected Publications

Harvanek ZM, Fogelman N, Xu K, Sinha R. Psychological and biological resilience modulates the effects of stress on epigenetic aging. Transl Psychiatry. 2021 Nov 27;11(1):601. doi: 10.1038/s41398-021-01735-7. PubMed PMID: 34839356; PubMed Central PMCID: PMC8627511.

Liang X, Justice AC, So-Armah K, Krystal JH, Sinha R, Xu K. DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations. Mol Psychiatry. 2021 Jun;26(6):2238-2253. doi: 10.1038/s41380-020-0668-x. Epub 2020 Feb 7. PubMed PMID: 32034291; PubMed Central PMCID: PMC8440221.

Shu C, Justice AC, Zhang X, Marconi VC, Hancock DB, Johnson EO, Xu K. DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population. Epigenetics. 2021 Jun-Jul;16(7):741-753. doi: 10.1080/15592294.2020.1824097. Epub 2020 Oct 22. PubMed PMID: 33092459; PubMed Central PMCID: PMC8216205.

Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. Nat Commun. 2020 Oct 20;11(1):5302. doi: 10.1038/s41467-020-18489-3. PubMed PMID: 33082346; PubMed Central PMCID: PMC7598939.

Hu Y, Ranganathan M, Shu C, Liang X, Ganesh S, Osafo-Addo A, Yan C, Zhang X, Aouizerat BE, Krystal JH, D'Souza DC, Xu K. Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1. PubMed PMID: 32103029; PubMed Central PMCID: PMC7044203.

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Also see: VA Mental Health