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PTSD: National Center for PTSD


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Medications for PTSD



This section is for Veterans, General Public, Family, & Friends

This section is for Veterans, General Public, Family, and Friends

Medications for PTSD

Available in Spanish: Medicamentos para el TEPT | Ver todos

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Medications that have been shown to be helpful in treating PTSD symptoms are some of the same medications also used for symptoms of depression and anxiety.

These are antidepressants, called SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors). The four antidepressants effective for treating PTSD are:


  • Sertraline (Zoloft)
  • Paroxetine (Paxil)
  • Fluoxetine (Prozac)


  • Venlafaxine (Effexor)

Note: Medications have two names: a brand name (for example, Zoloft) and a generic name (for example, Sertraline).

How Do They Work?

PTSD may be related to changes in the brain that are linked to our ability to manage stress. People with PTSD appear to have different amounts of certain chemicals (called neurotransmitters) in the brain than people without PTSD. SSRIs and SNRIs are believed to treat PTSD by putting these brain chemicals back in balance.

What Can I Expect?

To receive medications for PTSD, you'll need to meet with a provider who can prescribe these medications to you. Many different types of providers, including your family doctor and even some nurses and physician assistants, can prescribe antidepressant medications for PTSD. You and your provider can work together to decide which antidepressant medication may be best for you. In general, the four different SSRIs and SNRIs listed above appear to work equally well for PTSD.

Once you fill your prescription, you will begin taking a pill at regular time(s) each day. It may take a few weeks before you notice the effects of the medication. It is important to continue to take it even if you do not notice changes right away. You will meet with your provider every few months or so. Your provider will monitor your response to the medication (including side effects) and change your dose, if needed.

What Are the Risks?

The risks of taking SSRIs and SNRIs are mild to moderate side effects such as upset stomach, sweating, headache, and dizziness. Some people have sexual side effects, such as decreased desire to have sex or difficulty having an orgasm. Some side effects are short-term, though others may last as long as you are taking the medication.

Group or Individual?

You will attend regular one-on-one visits with the provider who prescribes you the medication.

Will I Talk in Detail about My Trauma?

No, you will not need to talk about the details of your trauma. However, your provider may ask for some basic information about your trauma - like the type of trauma and when it happened - when you first meet.

Will I Have Homework?

No, you will just need to take your medication as prescribed.

How Long Does Treatment Last?

You may start to feel better in about 4-6 weeks. You will need to keep taking the medication to keep getting the benefits.

Choosing the Best Treatment for You

Trying to figure out which PTSD treatment is best for you? For more videos about the four SSRIs and SNRIs used for PTSD and other treatments that work, get started with the PTSD Treatment Decision Aid.

Date this content was last updated is at the bottom of the page.

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The National Center for PTSD does not provide direct clinical care, individual referrals or benefits information.

PTSD Information Voice Mail:
(802) 296-6300
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Also see: VA Mental Health